The name Murciélago, means "bat" in Spanish, comes from a bull that survived 24 sword strokes in an 1879 fight at the arena of Córdoba, and fought with such passion and spirit that the matador chose to spare its life, a rare honor. In another Lamborghini tie-in, the bull was later presented as a gift to Don Antonio Miura, who was a noted breeder and whose bull ranch the Lamborghini Miura was named after, and went on to sire a line of famous fighting bulls.
The LP640 version was first shown at the Geneva Motor Show in March 2006, as a facelift for the coupé version. It features a 6.5 Liter engine, now producing 631 bhp (471 kW), improving performance substantially. Like the base Murciélago, the engine is mounted "backwards", with the transmission in front of the engine and the differential behind it, instead of a transaxle normally seen on mid-engine cars. There were also a few minor external changes, primarily to the low air intakes.
The front and rear bumpers have been reshaped to channel air more efficiently, and the new exhaust has been shaped into the rear diffuser to minimize aerodynamic lift. The air intake on the left side has been enlarged to accommodate the feeding of the oil cooler. The car's body is made up of steel and carbon fiber, while underneath a revised suspension has been added to keep up with the car's performance. It also has an all-wheel-drive system that normally distributes 70% of the torque to the rear wheels, but can allocate up to 100% to either end depending on where the grip is running out. There are also new 18-inch (460 mm) Hermera alloy wheels running huge 335/30 tires at the rear. The LP640 retains the original car's scissor-opening doors. The LP640 coupè U.S. MSRP rests at $318,800.
Inside the LP640, the seating has been reshaped to accommodate greater headroom, while an upgraded instrument panel is flanked by an improved stereo system.
The LP640's optional equipment includes ceramic brakes for swifter braking, chrome paddle shifters, and a glass engine cover which shows off the LP640's 6.5 Liter V12 engine.
A special edition version of the Murciélago LP640 was introduced at the Paris Motor Show. The Versace edition features a customized all-white exterior and a matching white interior. However, a 1-of-a-kind black LP640 Versace and LP640 Roadster Versace were also presented by the factory.
Lamborghini announced the LP640 Roadster version at the 2006 LA Auto Show.